Tobac PAK Details

Nicotine achieves its initial effects by disrupting the neurotransmitter acetylcholine. Like other neurotransmitters, acetylcholine has several different subtypes of receptor with which it can combine. One group, called nicotine receptors, can also be occupied by nicotine molecules. Unlike those of most other substances, however, nicotine's effects quickly spread to each of the four major neurotransmitters I've discussed. In other words, nicotine also disrupts serotonin, endorphins and enkephalins, dopamine, and GABA. To complicate matters further, nicotine's effects can vary dramatically from one person to the next. Many people use tobacco because it helps them concentrate and stay alert, while others use it to relax. Because it stimulates both inhibitory and excitatory neurotransmitters, nicotine is capable of both energizing and relaxing.